EVALUATION OF BONE REGENERATION BY OSTRICH EGG WHITE SUBSTITUTE IMPLANTED WITH BONE IN TIBIA BONE DEFECT IN ANIMAL MODEL

Abstract

The present study was conducted to investigate the in vivo to assess the effect of ostrich egg white (OEW)–derived graft substitutes on bone healing and comparative with self– regeneration of control site in dogs. The eight male domestic dogs (3–4 years old, weighing 20–30 kg) were used. Bone formation was assessed by using of OEW as kind of biomaterial that has flexibility and jelly shape with high compatibility. The implant was harvested after 4 and 8 weeks, and the area of new bone formation was quantified by radiology and densitometry studies. The highest bone formation was achieved with the OEW treatment, and it was significantly higher than that achieved with the empty treatment. The quantity of new bone at end of 8 weeks was greater than at 4 weeks in treated group. The researcher also show that Using OEW, the bone regeneration significantly increased within the implanted site in the biomaterial group, in the second month of the experiment, when compared to the control group. Furthermore, bone regeneration was significantly higher in the implant treatment biomaterial site of individual OEW, after implantation times, it’s showed little effect in enhancing bone regeneration 4 weeks post– implantation. Overall, it can be concluded that OEW (safe, cheap, and easily available) is a potent osteoidinductive component that plays critical role during bone regeneration and repairing in animal model. Keyword: Animal model, Bone regeneration, Implant, Ostrich egg, Tibia bone.