Corneal nerve plexus changes induced by Oxaliplatin chemotherapy and Ergothioneine antioxidant supplementation

Abstract

case, at the time of explanation the tissue appeared normal and there were no black particles visible. We suggest that the tissue reaction in our case was secondary to the remaining microscopic platinum particles following explanation. In 2016, a review of hypersensitivity reactions to implanted metal devices was performed with mention of cobalt, gold, copper, nickel and titanium causing hypersensitivity, but no specific mention of platinum. One described reaction was type IV hypersensitivity to cobalt-chromium particles acting as haptens to elicit immune responses manifesting as periprosthetic granulomatous pseudotumours. In conclusion, this case presents a rare complication of platinum chain eyelid implant used in the management of paralytic lagophthalmos.