Studies on the effects of 4-hydroxy isoleucine in experimentally induced inflammatory bowel disease

Abstract

Objective: The present study was designed to evaluate the effects of 4-Hydroxyisoleucine in experimentally induced Inflammatory Bowel Disease (IBD) in rats.Method: Wistar Albino rats weighing about 150-250 gm were employed in the study for induction of acetic acid and indomethacin induced IBD and assessed for various parameters like body weight, colon and intestinal damage, oxidative stress, total proteins and inflammation.Results: In this study 4-hydroxyisoleucine at two different doses was found to be successful in managing the serum and tissue homogenate changes in acetic acid induced UC and indomethacin induced CD possibly through its antioxidant and anti-inflammatory profile.Conclusions: 4-hydroxyisoleucine proved its antioxidant and anti-inflammatory profile by reducing the oxidative stress and inflammation, further it also improved the integrity of intestine thus amino acid, 4-hydroxyisoleucine was successful in mediating the changes induced by acetic acid and indomethacin induced experimental IBD in rats.