Remodeling of cardiac metabolism in heart failure with preserved ejection fraction

IF 2.5 Q2 PHYSIOLOGY
Akira Yoshii, Rong Tian
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引用次数: 1

Abstract

The remodeling of cardiac metabolism, such as changes in substrate utilization and mitochondrial dysfunction, has long been suggested to impair myocardial energetics that leads to energy starvation of the failing hearts. However, most of the studies to date focused on heart failure with reduced ejection fraction and the role of metabolism in the development of heart failure with preserved ejection fraction (HFpEF) is thus not well defined. Studies of cardiac metabolism in HFpEF are emerging with the recent progress in animal models. This review seeks to provide an overview of metabolic profile in HFpEF hearts from available reports and to highlight future research directions.

保留射血分数的心力衰竭患者心脏代谢的重构
长期以来,人们一直认为心脏代谢的重塑,如底物利用的改变和线粒体功能障碍,会损害心肌能量,导致衰竭心脏的能量饥饿。然而,迄今为止,大多数研究都集中在射血分数降低的心力衰竭上,因此,代谢在射血分数保持的心力衰竭(HFpEF)发展中的作用并没有很好的定义。随着动物模型的研究进展,HFpEF的心脏代谢研究正在兴起。本综述旨在从现有报告中概述HFpEF心脏的代谢概况,并强调未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Physiology
Current Opinion in Physiology Medicine-Physiology (medical)
CiteScore
5.80
自引率
0.00%
发文量
52
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