Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-09-30 DOI:10.37360/blacpma.22.21.5.40

M. E. Frias-Zepeda, Jorge Ibarra-Berumen, C. Ordaz-Pichardo, M. Rosales-Castro

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Abstract

Lippia graveolens HBK (Verbenaceae) is an aromatic herb of economic importance in Mexico, known as oregano. The leaves are usedas condiments, and people use this species for respiratory and digestive disorders. The aim of this work was to evaluate the cytotoxic effect of ethanolic extracts obtained from free-oil leaves (L9) and stem (S15), against lung cancer cell line SK-LU-1, through tetrazolium salt (MTT) assay. Extracts concentrations of 0.3 to 300 μg/mL were used and HFF-1 as normal control cells. Both L9 and S15 extracts, showed cytotoxic effect, although stem was stronger than leaves and without damage to normal cell control. The phenolic compounds caffeic acid and acacetin werein higher concentration in L9, whereas naringenin, taxifolin, eriodictyol, luteolin, and apigenin had higher concentrations in S15. The ethanolic extracts of L. graveolens have excellent cytotoxic activity, and have a wide possibility of use in lung cancer treatment.

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枸杞HBK叶和茎乙醇提取物对肺癌细胞株SK-LU-1的细胞毒活性

Lippia graveolens HBK(马鞭草科)是一种在墨西哥具有重要经济意义的芳香草本植物，被称为牛至。叶子被用作调味品，人们用它来治疗呼吸和消化系统疾病。本研究通过四氮唑盐(MTT)试验，评价了荷叶(L9)和茎(S15)乙醇提取物对肺癌细胞系SK-LU-1的细胞毒作用。提取液浓度为0.3 ~ 300 μg/mL, HFF-1为正常对照细胞。L9和S15提取物均表现出细胞毒作用，但茎强于叶，且不损害正常细胞控制。酚类化合物咖啡酸和阿卡辛在L9中含量较高，而柚皮素、杉木素、梧桐醇、木犀草素和芹菜素在S15中含量较高。枸杞醇提物具有良好的细胞毒活性，在肺癌治疗中具有广泛的应用前景。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.