Using Of Area Under The Curve Method For The Spectrophotometric Determination Of Betamethasone Sodium Phosphate In Its Pure And Pharmaceutical Forms

Abstract

A new, fast, accurate, economic, sensitive spectrophotometric method for the determination of Betamethasone (BSP) was developed. The method includes the use of the area under the curve (AUC) of the BMT UV-spectrum in methanol. This method was very suitable to the determination of BSP because it gave good linearity which up to 10-100 µg/ml, good accuracy and precision, through Rec% values which were ranged between 98.40914-101.40864% and RSD% values were ranged between 0.05507-0.97609%, LOD was 0.029701 µg/ml and LOQ was 0.098013 µg/ml. The method successfully applied to the determination of BSP in pure and trading forms.