Human umbilical cord-blood-derived mesenchymal stem cell can improve the clinical outcome and Joint space width after high tibial osteotomy.

D. Suh, Seung-Beom Han, W. Yeo, Kuhoang Cheong, Sang-Yeon So, B. Kyung
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引用次数: 4

Abstract

BACKGROUND There is limited study about the human umbilical cord-blood derived mesenchymal stem cell (hUCB-MSC) cartilage regeneration procedures combined with high tibial osteotomy (HTO). We compared the clinical and radiological results of hUCB-MSC cartilage regeneration procedures combined with HTO to those of microfracture with HTO. METHODS From August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm2 on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated. RESULTS A total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion. CONCLUSION hUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients.
人脐带血间充质干细胞可改善高位胫骨截骨术后的临床疗效和关节间隙宽度。
关于人脐带血源性间充质干细胞(hUCB-MSC)软骨再生手术联合胫骨高位截骨术(HTO)的研究有限。我们比较了hub - msc软骨再生联合HTO与微骨折联合HTO的临床和影像学结果。方法2017年8月至2018年12月,纳入国际软骨再生与关节保存学会(ICRS)评定的股骨内侧髁(MFC)软骨缺损超过200 mm2的HTO患者。为了进行比较,所有参与者分为两组:接受hub -MSC诱导的软骨再生手术(MSC组)和仅微骨折(C组,对照组)。临床采用特殊外科医院(HSS)、国际膝关节文献委员会(IKDC)和Lysholm评分于术后18个月进行评估。影像学上评估机械轴(MA)和关节间隙宽度(JSW)。结果共入组膝关节100例(MSC组43例,C组57例),MSC组IKDC评分(69分)优于C组(62分);p < 0.05)。MSC组JSW增加量(0.6 mm)大于C组(0.1 mm);p < 0.05)。没有患者出现骨不连、矫正丢失或关节置换。结论hub - mscs对HTO患者的临床疗效和JSW的改善效果优于单纯的微骨折。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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