The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Peihua Dong, Yu Huang, Y. Pu
{"title":"The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases","authors":"Peihua Dong, Yu Huang, Y. Pu","doi":"10.53941/ijddp.0201005","DOIUrl":null,"url":null,"abstract":"Review\nThe Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases\n\nPeihua Dong , Yu Huang , and Yujie Pu ,*\n\n\nDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China\n* Correspondence: yujiepu@cityu.edu.hk\n \n \nReceived: 29 December 2022\nAccepted: 18 January 2023\nPublished: 10 February 2023\n \n\nAbstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.","PeriodicalId":94047,"journal":{"name":"International journal of drug discovery and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of drug discovery and pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53941/ijddp.0201005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Review The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases Peihua Dong , Yu Huang , and Yujie Pu ,* Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China * Correspondence: yujiepu@cityu.edu.hk     Received: 29 December 2022 Accepted: 18 January 2023 Published: 10 February 2023   Abstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.
川芎嗪联合其他药物治疗心血管疾病的疗效观察
川芎嗪联合其他药物治疗心血管疾病的研究进展董培华,黄宇,濮玉杰,*香港城市大学生物医学科学系,香港518057 *通讯:yujiepu@cityu.edu.hk收稿:2022年12月29日收稿:2023年1月18日发表:摘要:川芎是中药之一,最早记载于唐代,具有活血化瘀的作用。川芎短段是川芎最有效的部位。经化学分析,川芎的主要化学成分为四甲基吡嗪。从那时起,人们进行了大量的探索,以检查四甲基吡嗪治疗不同疾病的效率,并了解其作用的潜在机制。川芎嗪(川芎芩)与川芎嗪一样,具有改善循环系统和神经系统功能的作用。在基础和临床研究中,川芎嗪与其他药物联合使用,在改善心血管健康或减轻化疗不良反应方面也取得了较好的效果。本文就川芎嗪与其他药物联合治疗心血管疾病的研究进展进行综述,并对川芎嗪今后的研究方向和更好地利用川芎嗪提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信