The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases

Peihua Dong, Yu Huang, Y. Pu
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引用次数: 1

Abstract

Review The Therapeutic Effects of Ligustrazine in Combination with Other Drugs in Cardiovascular Diseases Peihua Dong , Yu Huang , and Yujie Pu ,* Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 518057 , China * Correspondence: yujiepu@cityu.edu.hk     Received: 29 December 2022 Accepted: 18 January 2023 Published: 10 February 2023   Abstract: Chuanxiong, one of the traditional Chinese medicines (TCM), was first documented in the Tang dynasty to promote blood circulation and remove blood stasis. Ligusticum chuanxiong Hort was shown as the most effective portion of chuanxiong. Later chemical analysis revealed that the main chemical component of ligusticum chuanxiong Hort is tetramethylpyrazine. Since then, numerous explorations have been made to examine the efficiency of tetramethylpyrazine in treating different diseases and understand the underlying mechanisms of its action. Like Chuanxiong, ligustrazine (Chuan Xiong Qin) improved the functions of the circulatory and nervous systems. Ligustrazine (Chuan Xiong Qin) was also used in combination with other medicines to achieve better effects on improving cardiovascular health or alleviating the adverse effects of chemotherapies in both basic and clinical studies. The present review briefly summarizes the existing studies of the combination of ligustrazine (Chuan Xiong Qin) with other medicines in the treatment of cardiovascular diseases (CVDs) and provides valuable insights into the future research direction and better utilization of this drug.
川芎嗪联合其他药物治疗心血管疾病的疗效观察
川芎嗪联合其他药物治疗心血管疾病的研究进展董培华,黄宇,濮玉杰,*香港城市大学生物医学科学系,香港518057 *通讯:yujiepu@cityu.edu.hk收稿:2022年12月29日收稿:2023年1月18日发表:摘要:川芎是中药之一,最早记载于唐代,具有活血化瘀的作用。川芎短段是川芎最有效的部位。经化学分析,川芎的主要化学成分为四甲基吡嗪。从那时起,人们进行了大量的探索,以检查四甲基吡嗪治疗不同疾病的效率,并了解其作用的潜在机制。川芎嗪(川芎芩)与川芎嗪一样,具有改善循环系统和神经系统功能的作用。在基础和临床研究中,川芎嗪与其他药物联合使用,在改善心血管健康或减轻化疗不良反应方面也取得了较好的效果。本文就川芎嗪与其他药物联合治疗心血管疾病的研究进展进行综述,并对川芎嗪今后的研究方向和更好地利用川芎嗪提供有价值的见解。
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