FABRICATION OF TEST STRIP FOR SIBUTRAMINE HCl DETECTION IN SLIMMING TRADITIONAL HERBAL MEDICINE

Robi'atul Andawiyah, Novrynda Eko Satriawan, Jumaati
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Abstract

The development of an optical sensor-based test strip for the detection sibutramine HCl adulteration in traditional herbal products has been studied. The medium of the test strip was cellulosic paper immobilized with Dragendorff’s reagent and tetraethyl orthosilicate (TEOS) as the precursor using the sol-gel method. The presence of sibutramine HCl changed the color of the test strip from yellow to orange-red. The change in color was scanned and converted to RGB values using the ImageJ software. The intensity of the RGB value correlates with the concentration of the analyte. The performance of the test strip had good linearity in the range of 0,1-1,5 mM of sibutramine HCl, and the correlation coefficient (R) was 0,9872. The limit of detection, limit of quantification, precision (% RSD), and percentage of accuracy were 0,2 mM, 0,8 mM, less than 5%, and approximately 80-90%, respectively. The strip test is low cost and simple. Thus, it can be used as an alternative to detect sibutramine HCl in traditional herbal products.
减肥中药中盐酸西布曲明检测试纸条的研制
研究了一种用于传统中药产品中盐酸西布曲明掺假检测的光学传感器试纸条的研制。试纸的培养基采用溶胶-凝胶法,以Dragendorff试剂和正硅酸四乙酯(TEOS)为前驱体固定化纤维素纸。盐酸西布曲明的存在使试纸条的颜色由黄色变为橙红色。使用ImageJ软件扫描颜色变化并将其转换为RGB值。RGB值的强度与分析物的浓度有关。该试纸条在盐酸西布曲明0,1 ~ 1、5 mM范围内具有良好的线性关系,相关系数(R)为0,9872。检测限为0、2 mM,定量限为0、8 mM,精密度(% RSD)小于5%,准确度约为80 ~ 90%。试纸试验成本低,操作简单。因此,它可以作为检测传统草药产品中盐酸西布曲明的替代方法。
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