Irisin contributes to the hepatoprotective effect of vitamin D in a choline deficient diet induced nonalcoholic fatty liver disease rat model.

Hala Anwer, B. Hani, N. El-shaer, M. Allam
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Abstract

Non-alcoholic fatty liver disease (NAFLD) represents a growing cause of liver morbidity and mortality globally with no proven effective therapy yet. The aim of this research is to investigate the effect of vitamin D treatment on choline deficient (CD) diet-induced nonalcoholic fatty liver disease (NAFLD) like lesions in rats, with the possible involvement of irisin in this effect. Thirty-two rats were divided into 4 equal groups; control group, vitamin D group, CD diet group, CD diet+ vitamin D group. It was found that CD diet led to significant elevations in liver weight and index, serum liver enzymes, hepatic triglycerides (TG), malondialdehyde (MDA), inflammatory markers with significant decreases in serum 25-(OH) D3, irisin, hepatic antioxidants and peroxisome proliferator–activated receptor alpha (PPAR–α). Administration of vitamin D caused a significant improvement in all previous parameters, these results were supported by histopathological examination. It seems that vitamin D supplementation significantly reduced NAFLD induced by CD diet even in part due to irisin.
鸢尾素有助于维生素D在胆碱缺乏饮食诱导的非酒精性脂肪性肝病大鼠模型中的肝保护作用。
非酒精性脂肪性肝病(NAFLD)是全球肝脏发病率和死亡率日益增长的原因,目前尚无有效的治疗方法。本研究的目的是研究维生素D治疗对大鼠胆碱缺乏(CD)饮食引起的非酒精性脂肪性肝病(NAFLD)样病变的影响,鸢尾素可能参与了这种影响。32只大鼠分为4组;对照组、维生素D组、CD日粮组、CD日粮+维生素D组。结果发现,CD日粮显著升高了肝脏重量和指数、血清肝酶、肝脏甘油三酯(TG)、丙二醛(MDA)、炎症标志物,显著降低了血清25-(OH) D3、鸢尾素、肝脏抗氧化剂和过氧化物酶体增殖物激活受体α (PPAR - α)。服用维生素D可显著改善所有先前的参数,这些结果得到了组织病理学检查的支持。维生素D的补充似乎显著减少了由乳糜泻饮食引起的NAFLD,甚至部分原因是鸢尾素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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