Cellular Homeostasis and Repair in the Biliary Tree.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Seminars in liver disease Pub Date : 2022-06-07 DOI:10.1055/a-1869-7714

Wei Wang, Dongfeng Chen, Jun Wang, Liangzhi Wen

引用次数: 2

Abstract

The biliary tree comprises intrahepatic bile ducts and extrahepatic bile ducts lined with epithelial cells known as biliary epithelial cells (BECs). BECs are a common target of various cholangiopathies for which there is an unmet therapeutic need in clinical hepatology. The repair and regeneration of biliary tissue may potentially restore the normal architecture and function of the biliary tree. Hence, the repair and regeneration process in detail, including the replication of existing BECs, expansion and differentiation of the hepatic progenitor cells and biliary tree stem/progenitor cells, and transdifferentiation of the hepatocytes, should be understood. In this paper, we review biliary tree homeostasis, repair, and regeneration and discuss the feasibility of regenerative therapy strategies for cholangiopathy treatment.

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胆道树的细胞稳态和修复。

胆道树包括肝内胆管和肝外胆管，内衬上皮细胞称为胆道上皮细胞(BECs)。BECs是各种胆管疾病的共同靶点，在临床肝病学中有未满足的治疗需求。胆道组织的修复和再生有可能恢复胆道树的正常结构和功能。因此，详细了解修复和再生过程，包括现有BECs的复制，肝祖细胞和胆道树干/祖细胞的扩增和分化，以及肝细胞的转分化。本文综述了胆道树的稳态、修复和再生，并讨论了再生治疗胆管病的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in liver disease 医学-胃肠肝病学

CiteScore

8.20

自引率

2.40%

发文量

期刊介绍： Seminars in Liver Disease is a quarterly review journal that publishes issues related to the specialties of hepatology and gastroenterology. As the premiere review journal in the field, Seminars in Liver Disease provides in-depth coverage with articles and issues focusing on topics such as cirrhosis, transplantation, vascular and coagulation disorders, cytokines, hepatitis B & C, Nonalcoholic Steatosis Syndromes (NASH), pediatric liver diseases, hepatic stem cells, porphyrias as well as a myriad of other diseases related to the liver. Attention is also given to the latest developments in drug therapy along with treatment and current management techniques. Seminars in Liver Disease publishes commissioned reviews. Unsolicited reviews of an exceptional nature or original articles presenting remarkable results will be considered, but case reports will not be published.