Double layer coating system to prevent toxic reactions of titanium dioxide from the corrosion of dental implant fixtures

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
B. Goo
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引用次数: 0

Abstract

Introduction: Titanium dioxide has been classified by the International Agency for Research on Cancer (IARC) as a Group 2B carcinogen. As indispensable material for dental implant fixture, dental patients are exposed to its toxicological reactions. Objectives: The primary aim of this research is to prevent making nanoparticle titanium dioxide from the corrosion of dental implant fixture. Methods: The authors introduce double layer coating system for controlling corrosional toxicity of TiO2 from the surface of two dental implant fixtures by medronic acid and teriparatide acetate. Results: The first layer coated with medronic acid will generate phosphate bridges, functioning as a corrosionresistant sheath layer, and will be the only connector to Forteo (Teriparatide Acetate). The second layer encloses the essential elements of teriparatide like C, N, O and H with saving the functional radicals like CNO-, C2H3O-, CHO2-, C3H3O-, C2H3O2-,for and it will stimulate the coated implant fixture with PTH receptors, osteoblasts, and osteogenesis. The first layer covers Ti-O-P, acting as a titanium grade 4 antioxidant. Conclusion: The top surface ions in the second layer of the fixture have pharmaceutically functioning parts of the chemical structure of Teriparatide (C181H291N55O51S2) activating osteoblasts more than osteoclast, which leads to an overall increase in bone. Though the recommended duration of use for grade 4 implant fixtures is 3 years, but these new coated fixtures are expected to use the coated fixtures longer than 3 years by containing the stimulating effect of new alveolar bone formation by increasing the mineral density of the alveolar bone around the fixture besides preventing corrosional toxicity of the surface of pre-existing titanium fixtures.
双层涂层系统,防止二氧化钛腐蚀牙种植固定装置产生毒性反应
简介:二氧化钛已被国际癌症研究机构(IARC)列为2B类致癌物。作为种植牙固定物不可缺少的材料,其毒理学反应是牙科患者的直接暴露。目的:本研究的主要目的是防止纳米二氧化钛对种植牙固定物的腐蚀。方法:采用美地膦酸和醋酸特立帕肽双层涂层体系,控制两种种植体固定物表面TiO2的腐蚀毒性。结果:第一层涂覆美地膦酸将产生磷酸盐桥,作为耐腐蚀的护套层,并将成为Forteo (Teriparatide Acetate)的唯一连接器。第二层包裹了特立帕肽的基本元素,如C、N、O和H,保留了功能自由基,如CNO-、c2h30 -、CHO2-、c3h30 -、C2H3O2-,并刺激PTH受体、成骨细胞和成骨作用。第一层覆盖Ti-O-P,作为钛级4抗氧化剂。结论:夹具第二层顶表面离子具有特立帕肽(C181H291N55O51S2)化学结构的药理功能部分,对成骨细胞的激活作用大于破骨细胞,导致骨整体增加。虽然4级种植固定物的推荐使用时间为3年,但这些新的涂层固定物除了可以防止已有钛固定物表面的腐蚀毒性外,还可以通过增加固定物周围牙槽骨的矿物质密度来抑制新牙槽骨形成的刺激作用,因此预计涂层固定物的使用时间将超过3年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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