Time course of epigenetic modulation in response to concurrent exercise training in patients with schizophrenia

IF 0.6 Q3 VETERINARY SCIENCES

Comparative Exercise Physiology Pub Date : 2022-07-22 DOI:10.3920/cep210013

C. Lavratti, L. Iraci, A. Ferreira, G. Dorneles, D. Pochmann, M.C. da Rosa Boeira, A. Peres, V. Elsner

引用次数: 0

Abstract

This study aimed to investigate the short and long-term effects of concurrent exercise training on anthropometric variables, HDCA2 activity and cortisol levels of individuals with schizophrenia (SZ). Therefore, 10 patients were submitted to the program (endurance and strength exercises in the same session, 60 min of duration, three times a week) and blood samples were collected before, 30 days and 180 days after the intervention started. Exercise training reduced the body mass index and body mass after 180 days of the intervention. A significant decrease on HDAC2 activity was found 180 days after intervention compared to before the intervention. The cortisol levels remained unchanged in any evaluated time-points. The concurrent exercise training was able to modulate HDAC2 activity in mononuclear cells and improve anthropometric variables in a time-dependent manner in patients with SZ.

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精神分裂症患者并发运动训练后表观遗传调节的时间过程

本研究旨在探讨同步运动训练对精神分裂症(SZ)患者人体测量变量、HDCA2活性和皮质醇水平的短期和长期影响。因此，将10例患者纳入该方案(耐力和力量训练在同一阶段，持续时间为60分钟，每周3次)，并在干预开始前，30天和180天后采集血样。干预180天后，运动训练降低了身体质量指数和体重。与干预前相比，干预后180天HDAC2活性显著降低。皮质醇水平在任何评估时间点保持不变。同时运动训练能够调节单个核细胞中的HDAC2活性，并以时间依赖性的方式改善SZ患者的人体测量变量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comparative Exercise Physiology VETERINARY SCIENCES-

CiteScore

1.50

自引率

11.10%

发文量

期刊介绍： ''Comparative Exercise Physiology'' is the only international peer-reviewed scientific journal specifically dealing with the latest research in exercise physiology across all animal species, including humans. The major objective of the journal is to use this comparative approach to better understand the physiological, nutritional, and biochemical parameters that determine levels of performance and athletic achievement. Core subjects include exercise physiology, biomechanics, gait (including the effect of riders in equestrian sport), nutrition and biochemistry, injury and rehabilitation, psychology and behaviour, and breeding and genetics. This comparative and integrative approach to exercise science ultimately highlights the similarities as well as the differences between humans, horses, dogs, and other athletic or non-athletic species during exercise. The result is a unique forum for new information that serves as a resource for all who want to understand the physiological challenges with exercise.