3.3.3. Synthesis, structural characterization and antibacterial activity of bis(triorganotin) 2-butynedioates

Abstract

Two new bis(triorganotin) 2-butynedioates, R 3 SnOOCCoCCOOSnR 3 (where R = c -C 6 H 11 , 1 ; CH 2 C(CH 3 ) 2 C 6 H 5 , 2 ), have been synthesized and characterized by means of elemental analysis, IR, and NMR ( 1 H, 13C and 119 Sn) spectra. The crystal structure of complex 2 is determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate and tin atom is four-coordinate in solid and non-coordinating solvent. Complex 2 is a centrosymmetric di-nuclear tin complex in which tin atom adopts a distorted tetrahedral geometry. Bioassay results have shown that the complexes have good in vitro antibacterial activity against Escherichia coli .