Clinical characteristics of bronchiectasis-chronic obstructive pulmonary disease overlap syndrome

Abstract

Objective To analyze and summarize the clinical characteristics of patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap Syndrome (BCOS), so as to improve the understanding of the disease and guide the clinical work. Methods The clinical data of 490 patients diagnosed as acute exacerbation of chronic obstructive pulmonary disease in the Department of Respiratory and Critical Medicine, the First People′s Hospital of Shuangliu District, Chengdu from January 2018 to December 2018 were analyzed retrospectively.The population comprised 45 subjects with BCOS diagnosed by high resolution CT were divided into BCOS group.At the same time, among the remaining patients, 45 patients with simple COPD who were admitted to the Department of Respiratory and Critical Medicine were randomly selected as the control group.The differences in general data, clinical manifestations, pulmonary function, laboratory examination, hospitalization time and cost, acute aggravation times and readmission rate within 6 months after discharge were compared between the two groups. Results There was no significant difference in age, sex, smoking index, body mass index and basic medication between the two groups.The clinical symptoms of BCOS group were more severe than those of COPD group.Laboratory examination showed that Leukocyte count and the positive rate of procalcitonin was higher, the decrease of PaO2 value and Oxygenation index was more obvious, the positive rate of sputum culture was higher, the damage of pulmonary function was more significant, the hospitalization time was longer and the hospitalization cost was higher.The number of acute aggravation was more within 6 months after discharge. Conclusions The incidence of BCOS is higher, the clinical symptoms are more severe, the pulmonary function is more obvious, and the length of stay and cost are significantly higher.More attention should be paid to this kind of patients, early diagnosis and early treatment in order to improve the prognosis of patients. Key words: Pulmonary disease, chronic obstructive; Bronchiectasis-chronic obstructive pulmonary disease overlap syndrome; Chest high resolution CT; Lung function; Sputum culture