UV–VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF CHLORPROMAZINE HYDROCHLORIDE FROM PHARMACEUTICALS USING PLATINUM (IV) CHLORIDE

Abstract

The goal of this study is to develop a simple and precise spectrophotometric method for the quantitative determination of chlorpromazine hydrochloride (CPZ.HCL) by its reaction with platinum tetrachloride (PtC) in aqueous solutions (acidic medium) using UV-Vis spectrophotometry. Accordingly, a blue complex was formed having a characteristic band at 533 nm. To obtain high sensitivity and good stability, optimal reaction conditions were investigated, like the influence of pH, temperature, time, and the optimal concentration of platinum tetrachloride, as well as calibration curves were generated. Results indicated the possibility of using this method in estimating the drug above, as the calibration curve was subject to Beer's law for the range 5-75 µg/mL, and the molar absorptivity, Sandell's sensitivity, detection limit, and quantitative limit were 1563.32 L/mole·cm, 0.2272 µg/cm2 , 0.5102 and 1.7007 µg/mL respectively. The proposed procedure has also been successfully applied for CPZ·HCL quantification in the pharmaceutical form.