Prevalence of Extended Spectrum ß-Lactamase Producing Klebsiella Pneumoniae Isolates in A Tertiary Care Hospital in Bangladesh

Journal of National Institute of Neurosciences Bangladesh Pub Date : 2020-12-14 DOI:10.3329/jninb.v6i2.50763

S. J. Sonia, T. Ahsan, T. Ahmed, S. Nazneen, K. H. Uddin, S. Shamsuzzaman

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引用次数: 1

Abstract

Background: Extended-spectrum β lactamases (ESBLs) continue to be a major challenge in clinical setups world over, conferring resistance to the expanded-spectrum cephalosporins. Objectives: The aim of this study was to determine the prevalence of extended spectrum β-lactamase (ESBL) in strains of Klebsiella pneumoniae isolated from different clinical specimens in Dhaka Medical College Hospital, Dhaka, Bangladesh. Methodology: This cross sectional study was carried out at the Department of Microbiology of Dhaka Medical College, Dhaka, Bangladesh from July 2016 to June 2017. Klebsiella pneumoniae were isolated from different clinical specimens from adult hospitalized patients. These isolates were screened for ESBL production according to Clinical and Laboratory Standards Institute (CLSI) guidelines. ESBL production was confirmed by the phenotypic confirmatory double disc synergy test (DDST). Results: Among the 500 collected samples 75 Klebsiella pneumoniae were isolated. Among them, 68 isolates were selected for confirmatory tests of ESBL according to CLSI guidelines. Finally, 19 isolates were confirmed as ESBL producers by DDST (25.33%). Conclusion: In the present study, a large number of isolates are found to be ESBL producers. Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 101-104

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孟加拉国某三级医院产内酰胺酶肺炎克雷伯菌扩展谱流行病学研究

背景:广谱β内酰胺酶(ESBLs)仍然是世界各地临床设置的主要挑战，赋予对广谱头孢菌素的耐药性。目的:本研究的目的是确定从孟加拉国达卡医学院医院不同临床标本分离的肺炎克雷伯菌中扩展谱β-内酰胺酶(ESBL)的流行情况。方法:本横断面研究于2016年7月至2017年6月在孟加拉国达卡达卡医学院微生物学系进行。从成人住院患者的不同临床标本中分离到肺炎克雷伯菌。根据临床和实验室标准协会(CLSI)指南对这些分离株进行ESBL生产筛选。通过表型验证性双盘协同试验(DDST)证实了ESBL的产生。结果:500份标本中分离出肺炎克雷伯菌75株。根据CLSI指南，选取68株分离株进行ESBL确证试验。经DDST鉴定，19株菌株为ESBL产生菌，占25.33%。结论:本研究发现大量分离株为ESBL生产者。孟加拉国国家神经科学研究所学报，2020;6(2):101-104

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Journal of National Institute of Neurosciences Bangladesh

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