Implementation of Design of Experiments in Development and Optimization of Transfersomal Carrier system of Tacrolimus for the Dermal Management of Psoriasis in Albino Wistar Rat

Journal of Bioequivalence & Bioavailability Pub Date : 2018-01-01 DOI:10.4172/0975-0851.1000385

V. Parkash, Saurabh Maan, ana Chaudhary, Vikas Jogpal, G. Mittal, V. Jain

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引用次数: 13

Abstract

The present study was aimed to deal with development and optimization of transfersomal system for enhancement of transdermal drug delivery of tacrolimus drug for the treatment of psoriasis. Transfersomes containing tacrolimus was prepared by rotary evaporation method using Box- Behnken design. The levels of the drug, phosphatidylcholine and sodium desoxycholate (independent variables) were varied to study the influence on particle size, % entrapment efficiency and flux. The results of pharmacokinetic and pharmacodynamic studies proved that transfersomes were significantly superior in terms of drug permeation across the rat skin, with mean residence time of 52.58 ± 3.62 min. This was further confirmed by confocal laser scanning microscopic study. Transfersomes showed better antipsoriatic activities, compared to liposomes by virtue of better permeation through Wistar albino rat skin. Finally, it was concluded that the transfersomes accentuates the transdermal flux of tacrolimus and could be used for the management of psoriasis.

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他克莫司皮肤治疗白化Wistar大鼠银屑病转移体载体系统研制与优化实验设计的实现

本研究旨在开发和优化用于治疗银屑病的他克莫司药物经皮给药的转运体系统。采用Box- Behnken设计，采用旋转蒸发法制备了含他克莫司的转移体。改变药物、磷脂酰胆碱和去氧胆酸钠(自变量)的水平，研究对粒径、包封率和通量的影响。药代动力学和药效学研究结果表明，转移体在大鼠皮肤上的药物渗透能力明显优于转移体，平均停留时间为52.58±3.62 min。激光共聚焦扫描显微镜研究进一步证实了这一点。与脂质体相比，转移体通过Wistar白化大鼠皮肤的渗透性更好，显示出更好的抗银屑病活性。最后得出结论，该转移体可增强他克莫司的透皮通量，可用于银屑病的治疗。

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Journal of Bioequivalence & Bioavailability

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