Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach

Q4 Pharmacology, Toxicology and Pharmaceutics

Acta Marisiensis - Seria Medica Pub Date : 2021-12-01 DOI:10.2478/amma-2021-0033

Reka Annamaria Schmiedt, Robert Aurelian Tiucă, R. Tilinca, Lucia Mihaela Custură, Oana Deteșan, Brigitta Irén Bacso, Bianca Larisa Abalasei, A. C. Bell, Maria Alexandra Streza, M. Tilinca

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引用次数: 1

Abstract

Abstract Insulin resistance is a heterogenous condition with high prevalence in medical practice. As diabesity reaches epidemic levels worldwide, the role of insulin resistance is getting great importance. Contribution of risk factors like sedentary lifestyle, diets high in saturated fats and refined carbohydrates leads to this state with significant consequences. Besides its role in diabetes, insulin resistance is also associated with other several endocrine diseases, having not only a role in their development, but also to their treatment approach, evolution and even prognosis. The present review summarizes the current literature on the clinical significance of insulin resistance, as well as the possible underlying mechanisms and treatment options in order to achieve a high quality of life of these categories of patients. Deepening the role of inflammatory cytokines involved in insulin resistance paves the way for future research findings in this continuously evolving field.

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胰岛素抵抗是2型糖尿病发展的危险因素:一个系统的方法

胰岛素抵抗是一种异质性疾病，在医疗实践中具有很高的患病率。随着糖尿病在世界范围内的流行，胰岛素抵抗的作用越来越重要。久坐不动的生活方式、高饱和脂肪和精制碳水化合物的饮食等风险因素的贡献导致了这种状态的严重后果。胰岛素抵抗除了在糖尿病中起作用外，还与其他几种内分泌疾病有关，不仅与这些疾病的发生有关，而且与它们的治疗方法、演变甚至预后有关。本文综述了目前关于胰岛素抵抗的临床意义的文献，以及可能的潜在机制和治疗选择，以实现这类患者的高质量生活。深化炎症细胞因子在胰岛素抵抗中的作用，为这一不断发展的领域的未来研究发现铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

24 weeks