(Post) Covid-19 Panniculitis

Abstract

In its essence, panniculitis is the presence of an inflammatory infiltrate in the subcutaneous adipose tissue. Paniculitis as a clinical diagnosis encompasses a group of diseases that creates difficulties for both clinicians - dermatologists and histopathologists, mainly due to the many known forms of the disease, but also due to the various etiological reasons for their occurrence. Therefore, the clinical-pathological correlation plays an important role in the diagnosis. The development of various forms of panniculitis, in particular eosinophilic and generalized lymphocytic, have been described after Covid-19 infection.In the case of our patient, the development of panniculitis was observed after Covid-19 pneumonia. However, as additional etiological factors should be considered 1) the accompanying chronic diseases of the patient - congestive heart failure, hypertension and type 2 diabetes mellitus, which may also be etiological factors for the appearance of a certain form of panniculitis - stasis dermatitis / lipodermatosclerosis, 2) as well as the presence of probable bladder cancer - possible paraneoplastic genesis, 3) and the intake of enoxaparine - drug-induced panniculitis. Given the multifactorial genesis of panniculitis, the past infection with Covid-19, in our case, can be considered as a major trigger of the disease, which developed in the background of several etiological factors. For these reasons, our patient can also be diagnosed with post-Covid-19 panniculitis. Keywords: Lobular Panniculitis; Septal Panniculitis; Covid-19; Stasis Dermatitis; Corticosteroids; Paraneoplastic Reaction; Drug Induced Panniculitis