Evaluation of a Hydrophobic–Hydrophilic (Hydrogenated Castor Oil-Gum Tragacanth) Matrix using Propranolol Hydrochloride as Test Drug

The East and Central African Journal of Pharmaceutical Sciences Pub Date : 2008-12-15 DOI:10.4314/ECAJPS.V10I3.9766

R. Chigwanda, Pr Chinopfukutwa

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Abstract

An evaluation of propranolol hydrochloride release from hydrogenated castor oil–gum tragacanth matrices was carried out. The pH of the dissolution medium was found to affect propranolol hydrochloride release from such matrices. Acidic pH was found to enhance release while alkaline pH retarded release. This was attributed to possibly the effect of gum tragacanth matrix material or the propranolol hydrochloride itself. Either square root of time kinetics or first order kinetics could explain propranolol hydrochloride release mechanism from the hydrogenated castor oil–gum tragacanth matrices. Addition of hydrophobic hydrogenated castor oil matrix material to the hydrophilic gum tragacanth matrix was found to enhance release. This was attributed to possibly the disruption of the gum tragacanth matrix by the hydrophobic hydrogenated castor oil matrix material. Although gum tragacanth is primarily a hydrophilic material, it was found to have better release sustaining characteristics than the hydrophobic matrix material hydrogenated castor oil. Keywords : Hydrogenated castor oil, gum tragacanth, matrix, hydrophobic, hydrophilic East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp.68-71

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以盐酸心得安为试验药物评价疏亲水性(氢化蓖麻油胶)基质

对氢化蓖麻油胶石蜡基质中盐酸心得安的释放度进行了评价。发现溶解介质的pH值影响盐酸心得安从基质中释放。发现酸性pH促进释放，而碱性pH延缓释放。这可能是由于黄芪胶基质物质或盐酸心得安本身的影响。用平方根时间动力学或一阶动力学均可解释氢化蓖麻油胶石蜡基质中盐酸心得安的释放机理。将疏水氢化蓖麻油基质材料加入到亲水性胶石蜡基质中，可以促进释放。这可能是由于疏水氢化蓖麻油基质物质破坏了黄芪胶基质。虽然黄花胶主要是一种亲水性材料，但与疏水性基质材料氢化蓖麻油相比，它具有更好的缓释特性。关键词:氢化蓖麻油，黄芪胶，基质，疏水，亲水性，东非和中非医药科学杂志，Vol. 10 (3) 2007: pp.68-71

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The East and Central African Journal of Pharmaceutical Sciences

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