Chemoselective Synthesis of Aminobenzylic Derivative of Mackinazolinone and its X-ray Investigations

Abstract

The method for chemoselective synthesis of aminobenzylic derivative of the alkaloid mackinazolinone was developed and studied its structurein the crystal. It was found that reduction of Schiff base (intermediate, 4) by sodium borohydride at room temperature goes selectively through reduction only of azomethine (N=CH) bond; wherein does not affect the C=N double bond.