Small Cell Neuroendocrine Carcinoma of the Endometrium: Literature Review

Türkiye Klinikleri Journal of Case Reports Pub Date : 2020-01-01 DOI:10.5336/caserep.2019-72871

Nilgün Söğütçü, D. Yildirim

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Abstract

The article was prepared with the consent of the patient. We obtained the informed consent form from the patient. A 48-year-old perimenopausal woman presented to our gynecology outpatient clinic with vaginal bleeding and abdominal pain. In the routine biochemical study, fasting blood glucose was found to be 169.8 mg/dL, WBC 21.77 10^3/uL, CRP <2.00 mg/L, and HCT 40.3%. Since no clear pathology was detected in abdominal ultrasonography, endometrial curettage was performed for diagnostic purposes, which revealed a malignant epithelial tumor as pathological diagnosis. Afterwards, surgical treatment was planned and radical hysterectomy-bilateral salpingo-oopherectomypelvic and paraaortic lymphadenectomy was performed. Macroscopically, a malignant mass of 6.7x2 cm in size was found in the lower uterine segment. The microscopic study revealed a tumor with poorly differentiated small round cells located in the lower uterine segment-endometrium and associated with the cervical intraepithelial carcinoma. Tumor cells were present in the endometrium, endometrial polyp, and cervical stroma. However, they were not observed in cervical glands, fallopian tubes, and ovaries. Turkiye Klinikleri J Case Rep. 2020;28(2):99-102

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子宫内膜小细胞神经内分泌癌:文献综述

这篇文章是经病人同意编写的。我们从患者那里获得了知情同意书。一名48岁围绝经期妇女以阴道出血及腹痛就诊于妇科门诊。常规生化检查，空腹血糖169.8 mg/dL, WBC 21.77 10^3/uL, CRP <2.00 mg/L, HCT 40.3%。由于腹部超声未见明确病理，故行子宫内膜刮除诊断，病理诊断为恶性上皮性肿瘤。术后计划手术治疗，行根治性子宫切除-双侧输卵管-卵巢切除-盆腔及主动脉旁淋巴结切除术。镜下见子宫下段恶性肿块，大小6.7x2 cm。显微镜检查显示子宫下部子宫内膜有低分化的小圆形细胞，并与宫颈上皮内癌相关。肿瘤细胞存在于子宫内膜、子宫内膜息肉和宫颈间质中。然而，在宫颈腺、输卵管和卵巢中未观察到。中华医学杂志，2020;28(2):99-102

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Türkiye Klinikleri Journal of Case Reports

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