{"title":"Extraction of cephalosporin C using supported liquid membrane","authors":"A.C. Ghosh, S. Borthakur, M.K. Roy, N.N. Dutta","doi":"10.1016/0956-9618(95)00114-L","DOIUrl":null,"url":null,"abstract":"<div><p>As a step towards development of an efficient method for separation of cephalosporin C from fermentation broth, reactive extraction in supported liquid membrane has been investigated using simulated feed solution. Experiments were conducted in a diaphragm type cell with Celgard-2400 membrane as the solid support and Aliquat-336 as the carrier dissolved in butyl acetate as the diluent. Cephalosporin C was permeated across the membrane from an alkaline feed phase of carbonate buffer into an acidic strip solution of acetate buffer via a coupled transport phenomenon involving Cl ions. The permeation process was analyzed from the hypothesis of an overall transport dependance on diffusion across the liquid membrane and total re-extracting in the stripping phase.</p></div>","PeriodicalId":101160,"journal":{"name":"Separations Technology","volume":"5 2","pages":"Pages 121-126"},"PeriodicalIF":0.0000,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0956-9618(95)00114-L","citationCount":"22","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separations Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/095696189500114L","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 22
Abstract
As a step towards development of an efficient method for separation of cephalosporin C from fermentation broth, reactive extraction in supported liquid membrane has been investigated using simulated feed solution. Experiments were conducted in a diaphragm type cell with Celgard-2400 membrane as the solid support and Aliquat-336 as the carrier dissolved in butyl acetate as the diluent. Cephalosporin C was permeated across the membrane from an alkaline feed phase of carbonate buffer into an acidic strip solution of acetate buffer via a coupled transport phenomenon involving Cl ions. The permeation process was analyzed from the hypothesis of an overall transport dependance on diffusion across the liquid membrane and total re-extracting in the stripping phase.
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