SENSITIVITY VALUE OF IgA AND NS1 SEROLOGIC TEST IN EARLY DIAGNOSIS OF DENGUE INFECTION IN FEBRIS PATIENTS 3-5 DAYS, WHICH ONE IS MORE EFFECTIVE?

Abstract

The aim of this study was to determine the sensitivity level of IgA and NS1 serological tests in early diagnosis of dengue infection in febris patients 3–5 days in Cimahi. Next is to find out which of the two serological tests is the most effective for early diagnosis of dengue infection in febris patients for 3-5 days. The incidence and death rate due to dengue virus infection is still quite high, especially in several areas in Indonesia. The clinical manifestations of dengue virus infection are very diverse and the outcome of dengue infection (prognosis) is difficult to predict. An efficient and accurate diagnosis of dengue is the most important part of the patient care process. Serological examination is a laboratory diagnostic method that is often used to confirm the presence of dengue virus infection. NS1 and IgA anti-dengue are serologic tests that are often used, especially in the acute phase of the disease. This study aims to determine differences in the sensitivity of NS1 and IgA in patients with dengue infection with a fever of 3–5 days. This study was a prospective analytic observational study with a cross-sectional design. The subjects of this study were patients with dengue infection with a duration of 3-5 days. The number of samples that met the inclusion criteria was 69 people. The results of this study showed differences in the sensitivity of NS1 and IgA to antidengue in patients with dengue infection with a fever of 3-5 days. NS1 examination had the highest sensitivity value on the 3rd day of 75.0% and the lowest on the 5th day of 52.4%. Anti-dengue IgA examination had the lowest sensitivity value on the 3rd day of 10.0% and the highest on the 5th day of 42.9%.   Keywords : S1, IgA Antidengue, Dengue infection, sensitivity.