The Viscous and External Forces Effect on the Thermal Denaturation of Peyrard-Bishop Model

Abstract

The viscous and the external forces effect on thermal DNA denaturation of Peyrard-Bishop model are investigated. The calculation of the partition function to determine the stretching of hydrogen bonds has been performed by path integral Monte-Carlo. The result shows that the interaction between the viscous potential and external forces prevent DNA to unzip perfectly but allows DNA to split at a certain distance from its original position. The increase of the viscosity coefficient will reduce the melting temperature. The result obtained also showed how at certain temperature external potential give dominant contribution in denaturation, higher even than the viscosity effect.