EDA Fibronectin Isoform of Amniotic Fluid in Relation to Normal Pregnancy Stages and to Pregnancies Complicated by Fetal Postmaturity Syndrome

Abstract

Abstract The relative expression of the EDA region in fibronectin (FN) was determined by ELISA, using specific monoclonal antibody anti-EDA-FN, in the amniotic fluid samples derived from: 2nd trimester, early 3rd trimester, term, and post-term pregnancy, delivery at 37–40 weeks and at 41–42 weeks, as well as pregnancies complicated by fetal postmaturity. The expression of EDA-FN isoform was almost on the same level from the 2nd trimester to the 3rd trimester including term and post-term pregnancy. However, its relative amount significantly decreased in delivery groups and was significantly higher in the pregnancies with fetal postmaturity syndrome.