Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Ghufran A. ALHAMMADİ, Lamya A. SARSAM
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Abstract

A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol (BHA), is used to evaluate Metoclopramide hydrochloride (MCP.H) by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and it's pharmaceutical preparation by utilizing BHA as a reagent, (MCP.H) azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg / 5 mL, (i.e. 4-56 ppm) with a good sensitivity (molar absorptivity 0.26x104 L.mol-1. cm-1); good precision (RSD better than 0.844 %) and high accuracy (relative error less than + 0.4%), Sandell's sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection (LOD) is 0.0658 µg/mL and the evaluated limit of quantitation (LOQ) is 0.2193 µg/mL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.
新型绿色分光光度法测定制剂中盐酸甲氧氯普胺的含量
采用对环境危害较小的试剂2-叔丁基-4-甲氧基苯酚(BHA)对盐酸甲氧氯普胺(MCP.H)进行了简单、快速、灵敏、准确、精密的分光光度法评价。以BHA为试剂,盐酸甲氧氯普胺药物与药物制剂之间通过偶氮偶联反应,形成的偶氮染料在504 nm处显示出较高的吸收峰。吸光度-浓度关系在20 - 280µg / 5ml(即4-56 ppm)范围内呈线性关系,具有良好的灵敏度(摩尔吸光度0.26 × 104 l .mol-1 cm-1);精密度好(RSD大于0.844%),准确度高(相对误差小于+ 0.4%),Sandell的灵敏度指数为-0.1293µg。cm-2的计算检出限(LOD)为0.0658µg/mL,评价定量限(LOQ)为0.2193µg/mL。本方法对片剂和注射剂中盐酸甲氧氯普胺的含量测定取得了成功的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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