Role of Microvessel Density and Vascular Endothelial Growth Factor in Angiogenesis of Hematological Malignancies

R. Chand, H. Chandra, S. Chandra, S. Verma
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引用次数: 30

Abstract

Angiogenesis plays an important role in progression of tumor with vascular endothelial growth factor (VEGF) being key proangiogenic factor. It was intended to study angiogenesis in different hematological malignancies by quantifying expression of VEGF and MVD in bone marrow biopsy along with serum VEGF levels and observing its change following therapy. The study included 50 cases of hematological malignancies which were followed for one month after initial therapy along with 30 controls. All of them were subjected to immunostaining by anti-VEGF and factor VIII antibodies on bone marrow biopsy along with the measurement of serum VEGF levels. Significantly higher pretreatment VEGF scores, serum VEGF levels, and MVD were observed in cases as compared to controls (p < 0.05). The highest VEGF score and serum VEGF were observed in chronic myeloid leukemia and maximum MVD in Non-Hodgkin's Lymphoma. Significant decrease in serum VEGF levels after treatment was observed in all hematological malignancies except for AML. To conclude angiogenesis plays an important role in pathogenesis of all the hematological malignancies as reflected by increased VEGF expression and MVD in bone marrow biopsy along with increased serum VEGF level. The decrease in serum VEGF level after therapy further supports this view and also lays the importance of anti angiogenic therapy.
微血管密度和血管内皮生长因子在血液恶性肿瘤血管生成中的作用
血管生成在肿瘤的发展过程中起着重要作用,而血管内皮生长因子(VEGF)是促血管生成的关键因子。通过定量骨髓活检组织中VEGF和MVD的表达及血清VEGF水平,观察其治疗后的变化,研究不同血液恶性肿瘤的血管生成。该研究包括50例血液系统恶性肿瘤患者,在初始治疗后随访一个月,并与30例对照。骨髓活检行抗VEGF和因子VIII抗体免疫染色,测定血清VEGF水平。治疗前VEGF评分、血清VEGF水平、MVD均显著高于对照组(p < 0.05)。VEGF评分和血清VEGF以慢性髓系白血病最高,MVD以非霍奇金淋巴瘤最高。除AML外,所有血液系统恶性肿瘤治疗后血清VEGF水平均显著下降。结论血管生成在所有血液系统恶性肿瘤的发病机制中起重要作用,骨髓活检中VEGF表达和MVD升高,血清VEGF水平升高。治疗后血清VEGF水平的下降进一步支持了这一观点,也说明了抗血管生成治疗的重要性。
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