Nanoformulations enabled possible solutions for the management of psoriasis.

Abstract

Psoriasis is a chronic inflammatory disease with clinical manifestations of the skin that affect adults and children. It can have a significant negative impact on the physical, emotional, and, psychosocial wellbeing of affected patients. It has a strong genetic component but environmental factors such as infections can play an important role in the presentation of the disease. The patients suffering from a severe phase of this disease may have greater chances of occurrence of other diseases like cardiovascular disease, non-melanoma, and lymphoma. The present review majorly focuses on hallmarks of different types of psoriasis, evaluation of biomarkers to establish the severity and therapeutic response, and novel targeted therapies for the management of psoriasis. Potential herbal extracts and bioactive for the treatment of psoriasis are also highlighted here. A summary of pertinent, peer-reviewed English literature from databases like EBM, EMBASE, MEDLINE from 2010 to 2021 was used.