Y. Kurahashi, K. Furukawa, S. Sutandhio, L. H. Tjan, S. Iwata, Shigeru Sano, Y. Tohma, Hiroyuki Ohkita, Sachiko Nakamura, M. Nishimura, J. Arii, T. Kiriu, M. Yamamoto, T. Nagano, Y. Nishimura, Y. Mori
{"title":"Cross-neutralizing activity against Omicron could be obtained in SARS-CoV-2 convalescent patients who received two doses of mRNA vaccination","authors":"Y. Kurahashi, K. Furukawa, S. Sutandhio, L. H. Tjan, S. Iwata, Shigeru Sano, Y. Tohma, Hiroyuki Ohkita, Sachiko Nakamura, M. Nishimura, J. Arii, T. Kiriu, M. Yamamoto, T. Nagano, Y. Nishimura, Y. Mori","doi":"10.1101/2022.02.24.22271262","DOIUrl":null,"url":null,"abstract":"The SARS-CoV-2 variant Omicron is now under investigation. We evaluated cross-neutralizing activity against Omicron in COVID-19 convalescent patients who had received two doses of an mRNA vaccination. Surprisingly and interestingly, after the second vaccination, the subject neutralizing antibody titers including that against Omicron all became seropositive, and significant fold-increases were seen regardless of the subject disease severity. Our findings thus demonstrate that at least two doses of mRNA vaccination to SARS-CoV-2 convalescent patients can induce cross-neutralizing activity against Omicron.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"39 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indonesian Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2022.02.24.22271262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
The SARS-CoV-2 variant Omicron is now under investigation. We evaluated cross-neutralizing activity against Omicron in COVID-19 convalescent patients who had received two doses of an mRNA vaccination. Surprisingly and interestingly, after the second vaccination, the subject neutralizing antibody titers including that against Omicron all became seropositive, and significant fold-increases were seen regardless of the subject disease severity. Our findings thus demonstrate that at least two doses of mRNA vaccination to SARS-CoV-2 convalescent patients can induce cross-neutralizing activity against Omicron.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
