Historical and pathological overview of Castleman disease.

IF 0.9 Q4 HEMATOLOGY
Midori Filiz Nishimura, Yoshito Nishimura, Asami Nishikori, Tadashi Yoshino, Yasuharu Sato
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引用次数: 0

Abstract

Castleman disease consists of several lymphoproliferative subtypes that share some histological features in the lymph nodes. On the other hand, numerous clinical findings and etiologies make the disease challenging to understand. The origin of the disease is the hyaline vascular-type unicentric Castleman disease (UCD), first reported by Benjamin Castleman et al. in 1954. Although UCD is characterized by localized lesions and lack of symptoms, multicentric Castleman disease (MCD) with multiple lesions and systemic symptoms was reported by Frizzera in 1983. MCD is further divided according to KSHV/HHV8 infection status. In KSHV/HHV8-related MCD, viral infection signals lead to excessive cytokine production, and cause clinical and pathologic abnormalities. Some cases of plasma cell-type KSHV/HHV8-negative MCD can be found in association with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-proteins, and skin changes), which is a paraneoplastic syndrome. The others are idiopathic MCD, which are currently considered a heterogeneous group of diseases with overlapping pathological and clinical features. In this article, we summarize the historical evolution of Castleman disease to help understand the disease concept. We also review the latest ideas and definitions of the subtypes within the MCD spectrum and summarize the histopathological findings.

卡斯特曼病的历史和病理概述。
卡斯特曼病由多种淋巴增生亚型组成,这些亚型在淋巴结中具有一些共同的组织学特征。另一方面,众多的临床表现和病因也使该病难以理解。本杰明-卡斯特曼等人于 1954 年首次报道了透明血管型单中心卡斯特曼病(UCD)。虽然 UCD 以局部病变和无症状为特征,但 Frizzera 于 1983 年报道了多中心 Castleman 病(MCD),该病有多个病变和全身症状。MCD 根据 KSHV/HHV8 感染状态进一步划分。在 KSHV/HHV8 相关的 MCD 中,病毒感染信号导致细胞因子分泌过多,引起临床和病理异常。一些浆细胞型 KSHV/HV8 阴性 MCD 病例可与 POEMS 综合征(多发性神经病、器官肥大、内分泌病、M 蛋白和皮肤改变)并发,后者是一种副肿瘤综合征。其他是特发性 MCD,目前被认为是一组病理和临床特征相互重叠的异质性疾病。在本文中,我们总结了 Castleman 病的历史演变,以帮助理解该疾病的概念。我们还回顾了 MCD 病谱中亚型的最新观点和定义,并总结了组织病理学发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
6.70%
发文量
25
审稿时长
11 weeks
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