New formulation and activity of rhenium-platinum antitumor system

N. Shtemenko, D. Kytova, O. Berzenina, O. Hrabovska, A. Shtemenko
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Abstract

Two-component Rhenium-Platinum system (Re-Pt system) is based on administration of a cluster dirhenium(III) compound and cisplatin to tumor bearing animals followed by a significant antitumor effect and decreased toxic effect of cisplatin on normal cells. The aim of this work was to obtain solid lipid nanoparticles (SLN) from surface lipids (waxes) of Chelidonium majus L. (Papaveraceae) leaves and to estimate whether capsulation of dirhenium(III) as a component of the Re-Pt system into SLN will affect its antitumor activity and red blood cells (RBC) morphology in a rat model of Guerin’s carcinoma growth. Fourier-transform infrared spectroscopy, gas-liquid chromatography, microscopy, light scattering were used in the research. Solid lipid nanoparticles were obtained, characterized, loaded with cluster dirhenium(III) and being introduced together with cisplatin to rats with Guerin’s carcinoma resulted in RBC morphology preservation and a significant decrease in tumor weight. It was concluded that the lipid coating of the rhenium cluster compound did not reduce the antitumor effect of the Re-Pt system and protected RBC from toxic cisplatin influence­. A new formulation of the Re-Pt system is proposed. Keywords: carcinoma, rhenium cluster compound, rhenium-platinum antitumor system, solid lipid nanoparticles, surface lipids
铼-铂抗肿瘤体系的新配方及活性研究
双组分铼-铂系统(Re-Pt系统)是基于给药簇状的diheni (III)化合物和顺铂对荷瘤动物,随后显着的抗肿瘤作用和顺铂对正常细胞的毒性作用降低。本研究的目的是在大鼠Guerin癌模型中,从Chelidonium majus L. (Papaveraceae)叶片的表面脂质(蜡质)中获得固体脂质纳米颗粒(SLN),并评估作为Re-Pt系统组成部分的dihenium (III)被胶囊化是否会影响其抗肿瘤活性和红细胞(RBC)形态。采用傅里叶变换红外光谱法、气液色谱法、显微镜法、光散射法等研究方法。我们获得了固体脂质纳米颗粒,并对其进行了表征,该纳米颗粒装载了簇状dihenium (III),并与顺铂一起引入Guerin癌大鼠,结果是红细胞形态保持,肿瘤重量显著降低。综上所述,铼簇化合物的脂质包被不会降低Re-Pt系统的抗肿瘤作用,并能保护红细胞免受顺铂毒性的影响。提出了Re-Pt体系的新公式。关键词:癌,铼簇化合物,铼铂抗肿瘤体系,固体脂质纳米颗粒,表面脂质
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