Roger Tsien – our colorful colleague 1952–2016

IF 7.2 2区生物学 Q1 BIOPHYSICS

Quarterly Reviews of Biophysics Pub Date : 2018-02-27 DOI:10.1017/S0033583517000154

D. Lilley, B. Nordén

引用次数: 0

Abstract

Roger Tsien did more than anyone else in the application of fluorescent materials in biological sciences. He is undoubtedly best known for his development of the intrinsically fluorescent proteins and their many uses in cell biology and neurobiology. The original such protein is, of course, GFP, but Roger used genetic engineering methods to create a whole range of such proteins with different photophysical properties tuned to particular needs. In addition, he developed fluorescent probes such as Fura-2 that permitted calcium ions to be detected in cells, and this was extended to dyes that allowed the detection of other metal ions. Roger applied his science in medicine to great practical benefit, for example in the development of fluorescent peptides that would allow surgeons to visualize nerves thereby to avoid damaging them during surgery. His inventiveness extended to the commercial sector. Roger held many patents and was involved in setting up a number of companies. Roger Y. Tsien 1952–2016 Photo: The Royal Society.

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Roger Tsien -我们的同事1952-2016

钱永健在荧光材料在生物科学中的应用方面比任何人都做得多。毫无疑问，他最出名的是他的内在荧光蛋白的发展及其在细胞生物学和神经生物学中的许多应用。最初的这种蛋白质当然是绿色荧光蛋白，但罗杰用基因工程的方法创造了一系列具有不同光物理性质的蛋白质，以适应特定的需要。此外，他还开发了荧光探针，如Fura-2，可以检测细胞中的钙离子，并将其扩展到可以检测其他金属离子的染料。罗杰将他在医学上的科学应用到实际中，例如，在荧光肽的开发中，外科医生可以看到神经，从而避免在手术中损伤它们。他的创造力扩展到了商业领域。罗杰拥有许多专利，并参与建立了许多公司。钱存训1952-2016图片来源:英国皇家学会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quarterly Reviews of Biophysics 生物-生物物理

CiteScore

12.90

自引率

1.60%

发文量

期刊介绍： Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.