The effect of bendroflumethiazide (Centyl) on the renal excretion of calcium and sodium in normal, parathyroidectomized, thyroidectomized and thyroparathyroidectomized rats.

Abstract

The effect of administration of bendroflumethiazide in supramaximal doses on calcium and sodium excretion in intact, parathyroidectomized (PX), thyroidectomized (TX) and thyroparathyroidectomized (TPX) rats has been investigated. In all the groups the thiazide compound causes reduction in renal calcium excretion. In intact rats but not in the PX, TX, or TPX groups, an increased urinary excretion of calcium is seen after cessation of thiazide administration. The calcium concentration in the serum is not changed during thiazide administration. No accumulation of calcium in the aortic, heart or muscle tissue can be detected during thiazide administration. The benzothiadiazine diazoxide (proglicem®) does not cause any change in renal calcium excretion. A change in the ratio of parathormone/calcitonin concentration appears to take place during thiazide administration.