Synthesis and Anti-inflammatory Activity of Some Newer Potential Isoxazoline Derivatives of Indole

Abstract

Some new 3-acetyl-2-carboxy-5-methoxy indole (1), 2-carboxy-5-methoxy-3indolyl chalcones (2-6), 3-(2’-carboxy-5’-methoxyindol-3’-yl)-5-(substituted phenyl)-2-isoxazolines (7-11), 3-(2’carboxy-5’-methoxyindol-3’-yl)4-(substituted phenyl) aminomethyl-5-(substituted phenyl)-2isoxazolines (12-26) derivatives of indole have been synthesized in the present study. All the prepared compounds have been characterized by elemental and spectral analysis. All the above said compounds have been evaluated for their anti-inflammatory activity and some of them have been found as potential anti-inflammatory agents.