Radiotherapy and Chemotherapy in Low-Grade Glioma (LGG)

Abstract

Although optimal timing is unclear, but radiotherapy is an important component of therapy for LGG. Early and delayed radiotherapy can be used for LGG depending on some factors like tumor associated symptoms and presence of risk factors determining the outcome. Poor prognostic factors can be incomplete resection, MIB-1 index elevation, astrocytic histology, more than 40 year of age, absence of 1p/19q-codeletion, large sizes and mutation in isocitrate dehydrogenase. In some studies, with using 50-54 Gy RT dose with 1.8 Gy per fraction, the overall survival rates were similar between the patients whom received radiotherapy in early phase or during progression phase of the disease [1-5].