Intestinal Delivery Techniques for Live Microorganisms: A Brief Overview

Abstract

The gut microbiome is a critical determinant of human health and disease status. Administration of live microorganisms has emerged as an effective way to recover damaged gut microbiome for improving host health. However, live microorganisms are susceptible to various environmental stresses, including acidic pH during the gastric transit. Thus, appropriate delivery techniques are required to protect the live microorganisms during their transit to the target area and ensure their release at a desired location such as ileum or ascending colon. In this review, we provide an overview of intestinal delivery techniques for live microorganisms.