Topology-based protein–protein interaction analysis of oral cancer proteins

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Current Science Pub Date : 2022-11-25 DOI:10.18520/cs/v123/i10/1216-1224

Keerti Yadav, A. K. Singh

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引用次数: 1

Abstract

Oral cancer is a common type of head and neck cancer that affects majority of the population worldwide. The present study focuses on the network-based protein– protein interaction (PPI) approach for the identification of oral cancer targets and systems biology approach-based analysis. Totally 47 oral cancer gene targets were extracted from the BioXpress database, Oral Cancer Gene Database and HNC database. The related protein networks were explored and visualized using Cytoscape v3.7.2. Topology predictions were performed by Molecular Complex Detection tool and Biological Networks Gene Ontology tool (BiNGO) plug-in from Cytoscape v3.7.2. The comprehensive study using MCODE are three clusters of 15 common oral cancer genes. The predicted proteins were GSK-3 β , PKM, Catenin- β 1, Tp53, SMAD-3, MYC, LDHA, HIF1- α , PDPK-1, AKT3, PIK3CA, ILK, UBC, E2F1 and SKP. The 15 oral cancer genes with their significant P -value < 0.05 are responsible for the development of oral cancer. These 15 proteins obtained from network-based interaction analysis can be a potential solution of anti-cancer drug molecules against multiple targets of oral cancer.

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基于拓扑的口腔癌蛋白-蛋白相互作用分析

口腔癌是一种常见的头颈部癌症，影响着全世界大多数人口。目前的研究重点是基于网络的蛋白-蛋白相互作用(PPI)方法用于口腔癌靶点的识别和基于系统生物学方法的分析。从BioXpress数据库、口腔癌基因数据库和HNC数据库中共提取47个口腔癌基因靶点。使用Cytoscape v3.7.2对相关蛋白网络进行了探索和可视化。拓扑预测由Cytoscape v3.7.2中的分子复合物检测工具和生物网络基因本体工具(BiNGO)插件执行。使用MCODE对15个常见口腔癌基因进行了三组的综合研究。预测蛋白为GSK-3 β、PKM、Catenin- β 1、Tp53、SMAD-3、MYC、LDHA、HIF1- α、PDPK-1、AKT3、PIK3CA、ILK、UBC、E2F1和SKP。15个显著P值< 0.05的口腔癌基因与口腔癌的发生有关。通过网络相互作用分析获得的这15种蛋白可能是针对口腔癌多靶点的抗癌药物分子的潜在解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Science 综合性期刊-综合性期刊

CiteScore

1.50

自引率

10.00%

发文量

审稿时长

3 months

期刊介绍： Current Science, published every fortnight by the Association, in collaboration with the Indian Academy of Sciences, is the leading interdisciplinary science journal from India. It was started in 1932 by the then stalwarts of Indian science such as CV Raman, Birbal Sahni, Meghnad Saha, Martin Foster and S.S. Bhatnagar. In 2011, the journal completed one hundred volumes. The journal is intended as a medium for communication and discussion of important issues that concern science and scientific activities. Besides full length research articles and shorter research communications, the journal publishes review articles, scientific correspondence and commentaries, news and views, comments on recently published research papers, opinions on scientific activity, articles on universities, Indian laboratories and institutions, interviews with scientists, personal information, book reviews, etc. It is also a forum to discuss issues and problems faced by science and scientists and an effective medium of interaction among scientists in the country and abroad. Current Science is read by a large community of scientists and the circulation has been continuously going up. Current Science publishes special sections on diverse and topical themes of interest and this has served as a platform for the scientific fraternity to get their work acknowledged and highlighted. Some of the special sections that have been well received in the recent past include remote sensing, waves and symmetry, seismology in India, nanomaterials, AIDS, Alzheimer''s disease, molecular biology of ageing, cancer, cardiovascular diseases, Indian monsoon, water, transport, and mountain weather forecasting in India, to name a few. Contributions to these special issues ‘which receive widespread attention’ are from leading scientists in India and abroad.