NANODISPERSIONS OF LIPOIC ACID: PRODUCTION AND STUDY OF INFLUENCE ON FUNCTIONAL ACTIVITY OF PLATELETS

http://eng.biomos.ru/conference/articles.htm Pub Date : 2021-01-01 DOI:10.37747/2312-640x-2021-19-101-104

A. M. Inshakova, E. Darnotuk, A. Shipelova, N. Shastina, O. Baranova, A. Chekanov, K. Kazarinov, E. Solovieva, A. Fedin

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Abstract

Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possessing stability during long-term storage at room temperature. It was revealed that liposomes and LA NPs inhibit platelet aggregation caused by arachidonic acid, and the mechanism of antiplatelet action was proposed.

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硫辛酸纳米分散体的生产及其对血小板功能活性影响的研究

制备了粒径为50 ~ 250 nm的硫辛酸(LA)纳米分散体(脂质体和纳米乳液)，其包封率(EI)为80±10%，从纳米结构中缓释，室温长期保存稳定。结果表明，脂质体和LA NPs可抑制花生四烯酸引起的血小板聚集，并提出其抗血小板作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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http://eng.biomos.ru/conference/articles.htm

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