Molecular docking, isolation and biological evaluation of Rhizophora mucronata flavonoids as anti-nociceptive agents

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI:10.1016/j.bionut.2014.08.002

Selvaraj Gurudeeban , Satyavani Kaliamurthi , Haja Sherief Sheik , Ramanathan Thiruganasambandam

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引用次数: 9

Abstract

The anti-nociceptive effect of Rhizophora mucronata was evaluated on chemically and thermally induced nociception in mice. Albino mice received a dose of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction (Alk-CF) of R. mucronata by oral administration. Compared with controls, Alk-CF decreased the writhing numbers (P < 0.01) in a dose-dependent manner. Further, we determined that Alk-CF contained, a potent compared to control, also potent anti-nociceptive agent that acted via opioid receptors and using HPLC, identified this compound as luteolin. Docking simulation demonstrated that luteolin interacted strongly with cyclooxygenase, forming a number of specific hydrogen bonds. This study identified peripheral and central anti-nociceptive activities of R. mucronata that involve opioid receptor, and in which the active compound is luteolin as a source of new anti-nociceptive agent.

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根参黄酮抗伤害性药物的分子对接、分离及生物学评价

通过化学诱导和热诱导小鼠伤害感受的实验，评价了根参的抗伤害感受作用。白化病小鼠分别口服10、15、20或25 mg/kg的麻麻碱氯仿部分(Alk-CF)。与对照组相比，Alk-CF减少了扭动次数(P <0.01)，呈剂量依赖性。此外，我们确定Alk-CF含有一种有效的抗伤害剂，与对照组相比，它通过阿片受体起作用，并使用HPLC鉴定了这种化合物为木犀草素。对接模拟表明，木犀草素与环加氧酶相互作用强烈，形成了一些特定的氢键。本研究确定了麻草的外周和中枢抗痛觉活性与阿片受体有关，其中木犀草素是一种新的抗痛觉活性物质。

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Biomedicine & Preventive Nutrition

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