Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs

ECSOC-25 Pub Date : 2021-11-13 DOI:10.3390/ecsoc-25-11677
Tania Mazuelo, S. Serrano, Fernando García-Garrido, Josué Jiménez, Carolina Díaz-Norambuena, B. L. Maroto, Florencio Moreno, J. Bañuelos, A. R. Agarrabeitia, Ángeles Villanueva, S. D. L. Moya, M. Ortiz
{"title":"Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs","authors":"Tania Mazuelo, S. Serrano, Fernando García-Garrido, Josué Jiménez, Carolina Díaz-Norambuena, B. L. Maroto, Florencio Moreno, J. Bañuelos, A. R. Agarrabeitia, Ángeles Villanueva, S. D. L. Moya, M. Ortiz","doi":"10.3390/ecsoc-25-11677","DOIUrl":null,"url":null,"abstract":": Two analogues of a previous mitochondria-targetable theragnostic styrylBODIPY have been designed, synthesized and submitted to preliminary studies in order to explore their capability to act as new theragnostic agents with absorption in the red region. The new dyes are obtained through a straightforward and low-cost synthetic protocol, and have styryl moieties bearing non-delocalized cations (trimethylammonium) attached to the BODIPY through a spacer, or directly linked. Preliminary results over of them in cell bioimaging showed internalization into HeLa cells and accumulation into mitochondria. Photodynamic therapy was also analyzed, demonstrating the viability of this red styrylBODIPY as mitochondria-targetable phototheragnostic agent.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ECSOC-25","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ecsoc-25-11677","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

: Two analogues of a previous mitochondria-targetable theragnostic styrylBODIPY have been designed, synthesized and submitted to preliminary studies in order to explore their capability to act as new theragnostic agents with absorption in the red region. The new dyes are obtained through a straightforward and low-cost synthetic protocol, and have styryl moieties bearing non-delocalized cations (trimethylammonium) attached to the BODIPY through a spacer, or directly linked. Preliminary results over of them in cell bioimaging showed internalization into HeLa cells and accumulation into mitochondria. Photodynamic therapy was also analyzed, demonstrating the viability of this red styrylBODIPY as mitochondria-targetable phototheragnostic agent.
探索新的线粒体靶向治疗性styylbodipys
研究人员设计、合成了两种线粒体靶向治疗药物styrylBODIPY的类似物,并将其提交到初步研究中,以探索它们作为红色区域吸收的新治疗药物的能力。新染料是通过一种简单、低成本的合成方法获得的,其苯乙烯基部分含有非离域阳离子(三甲基铵),通过间隔剂连接到BODIPY上,或直接连接。细胞生物成像的初步结果显示,它们内化到HeLa细胞并积聚到线粒体中。光动力疗法也进行了分析,证明了这种红色styrylBODIPY作为线粒体靶向光疗诊断剂的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信