Health and Economic Impacts of Lockdown Policies in the Early Stage of COVID-19 in the United States

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Alireza Boloori, S. Saghafian
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引用次数: 0

Abstract

Lockdown policies, such as stay-at-home orders, are known to be effective in controlling the spread of the novel coronavirus disease 2019. However, concerns over economic burdens of these policies rapidly propelled U.S. states to move toward reopening in the early stage of the pandemic. Decision making in most states has been challenging, especially because of a dearth of quantitative evidence on health gains versus economic burdens of different policies. To assist decision makers, we study the health and economic impacts of various lockdown policies across U.S. states and shed light on policies that are most effective. To this end, we make use of detailed data from 50 U.S. states plus the District of Columbia on various factors, including number of tests, positive and negative results, hospitalizations, ICU beds and ventilators used, residents’ mobility obtained from cellphone data, and deaths. Our analyses allow quantifying the total cost versus the total quality-adjusted life year (QALY) associated with various lockdown policies. We utilize a compartmental model with Markov chain Monte Carlo simulation to estimate the spread of disease. To calibrate our model separately for each U.S. state, we make use of empirical data on the intensity of intervention policies, age, ratio of Black/Hispanic populations, per capita income, residents’ mobility, and number of daily tests and feed them to a longitudinal mixed-effect model. Finally, we utilize a microsimulation model to estimate the total cost and total QALY for each state and perform cost-effectiveness analysis to identify policies that would have worked best. Our results show that, compared with no intervention during March–June 2020, the policies undertaken across the United States saved, on average, about 41,284.51 years’ worth of QALY (per 100K capita), incurring $164.01 million (per 100K capita). Had the states undertaken more strict policies during the same time frame than those they adopted, these values would be 44,909.41 years and $117.28 million, respectively. By quantifying the impact of various lockdown policies separately for each state, our results allow federal and state authorities to avoid following a “one size fits all” strategy and instead enact policies that are better suited for each state. Specifically, by studying the trade-offs between health gains and economic impacts, we identify the particular states that would have benefited from implementing more restrictive policies. Finally, in addition to shedding light on the impact of lockdown policies during our study period (March–June 2020), our results have important implications on curbing future fast-spreading variants of the coronavirus or other related potential epidemics. Supplemental Material: The online appendix is available at https://doi.org/10.1287/serv.2023.0321 .
美国COVID-19早期封锁政策对健康和经济的影响
众所周知,居家令等封锁政策在控制2019年新型冠状病毒病的传播方面是有效的。然而,由于担心这些政策带来的经济负担,美国各州在疫情初期迅速转向重新开放。大多数州的决策一直具有挑战性,特别是因为缺乏关于不同政策的健康收益与经济负担的定量证据。为了帮助决策者,我们研究了美国各州各种封锁政策对健康和经济的影响,并阐明了最有效的政策。为此,我们利用了来自美国50个州和哥伦比亚特区的各种因素的详细数据,包括检测次数、阳性和阴性结果、住院情况、ICU床位和使用的呼吸机、从手机数据中获得的居民流动性以及死亡人数。我们的分析可以量化与各种封锁政策相关的总成本与总质量调整寿命年(QALY)。我们利用一个带有马尔可夫链蒙特卡罗模拟的室室模型来估计疾病的传播。为了分别为美国各州校准我们的模型,我们利用了干预政策强度、年龄、黑人/西班牙裔人口比例、人均收入、居民流动性和每日测试次数等经验数据,并将这些数据输入纵向混合效应模型。最后,我们利用微观模拟模型来估计每个州的总成本和总质量,并进行成本效益分析,以确定最有效的政策。我们的研究结果表明,与2020年3月至6月没有干预相比,美国各地采取的政策平均节省了约41,284.51年的QALY(每10万人均),产生了1.6401亿美元(每10万人均)。如果各州在同一时间段内采取比它们所采取的更严格的政策,这些价值将分别为44,909.41年和1.1728亿美元。通过分别量化各种封锁政策对每个州的影响,我们的研究结果使联邦和州当局能够避免遵循“一刀切”的策略,而是制定更适合每个州的政策。具体而言,通过研究健康收益和经济影响之间的权衡,我们确定了将从实施更多限制性政策中受益的特定州。最后,除了揭示我们研究期间(2020年3月至6月)封锁政策的影响外,我们的研究结果对遏制未来快速传播的冠状病毒变体或其他相关潜在流行病具有重要意义。补充材料:在线附录可在https://doi.org/10.1287/serv.2023.0321上获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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