Microbial Transformation of Danazol

Abstract

Danazol (17 -hydroxy-17 -pregna-2,4-dien-20-yno-[2,3- d ] isoxazole) ( 1 ) on fermentation with Fusarium lini , Aspergillus niger , and Cephalosporium aphidicola yielded 17 -hydroxy-2-(hydroxymethyl)-17- -pregn-4-en-20-yn-3-one ( 2 ) and 17 -hydroxy-2-(hydroxymethyl)-17 -pregna-1,4-dien-20-yn-3-one ( 3 ), while the fermentation of 1 with Bacillus cerus yielded compound 2 only.