FUNCTION OF AC-GLOBULIN AND LIPID IN BLOOD CLOTTING.

W. Seegers, E. Cole, N. Aoki
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引用次数: 12

Abstract

In this kinetic study of prothrombin activation prothrombin, thrombin, autoprothrombin C, autoprothrombin I, and Ac-globulin were used in purified form. The lipids used were protein-free sedimentable brain thromboplastin and crude "cephalin". Ac-globulin changed the substrate specificity of autoprothrombin C so that the latter really functions quite as another enzyme designated autoprothrombin C-AcG. The enzyme specificity of thrombin was also changed with Ac-globulin. The modified enzyme is designated thrombin-AcG. The two enzymes from prothrombin function in autocatalysis, and Ac-globulin is a co-autocatalyst. Thrombin-AcG is relatively a weaker enzyme than autoprothrombin C-AcG. With brain thromboplastin and Ac-globulin the two activation products are thrombin and autoprothrombin C. If the two procoagulants, brain thromboplastin and Ac-globulin, are in low concentration, autoprothrombin I compensates for the deficiency. In a typical prothrombin activation the microgram proportions of prothrombin, Ac-gl...
ac -球蛋白和脂质在凝血中的作用。
在这个凝血酶原活化的动力学研究中,凝血酶原、凝血酶、自身凝血酶C原、自身凝血酶I原和ac -球蛋白被纯化。所使用的脂质为无蛋白沉积性脑凝血活蛋白和粗“脑磷脂”。ac -球蛋白改变了自身凝血酶C原的底物特异性,使后者的功能与另一种称为自身凝血酶C- acg的酶完全相同。凝血酶的酶特异性也随ac -球蛋白而改变。这种修饰酶被命名为凝血酶acg。凝血酶原中的两种酶在自催化中起作用,ac -球蛋白是一种自催化剂。凝血酶acg是一种相对弱于自身凝血酶C-AcG的酶。对于脑凝活素和ac -球蛋白,两种激活产物是凝血酶和自身凝血酶原c。如果两种促凝剂,脑凝活素和ac -球蛋白浓度低,自身凝血酶原I弥补不足。在典型的凝血酶原活化中,凝血酶原的微克比例,Ac-gl…
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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