Evaluation of the damage of optic nerve after acute primary angle closure glaucoma

中国实用眼科杂志 Pub Date : 2017-06-10 DOI:10.3760/CMA.J.ISSN.1006-4443.2017.06.005

Qing Zhang, Hengli Zhang, Guangxian Tang, Min Wang, Dandan Liu, Fan Li, Hua Yu, Li Li

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Abstract

Objective To investigate the changes in thickness of retinal nerve fiber layer (RNFL) and visual fields following the initial acute attack of acute primary angle closure glaucoma (APACG) within 1 year. Methods A prospective cohort study. 30 consecutively recruited patients with APACG were observed (the attacked eye was as the observed eye while the fellow eye as control). At 6 time points (after intraocular pressure controlled for 24 hour, 1 week, 1 month, 3 month, 6 month, 12 month), intraocular pressure (IOP), RNFL thickness and Humphrey perimeter were analyzed. Results Compared with the control group, the average RNFL thickness in the observed group were thicker at 24 hour and 1 week (P 0.05). The thickness of averaged RNFL was positively correlated with the MD (P <0.05). Conclusions The thickness of the RNFL in patients with APACG is diffusely increasing after the acute attack for the first time, which is gradually thinner with the time going. However,it is stable after IOP con-trolled for 6 months; Perimetric damaged is reversible at the 1 month after IOP controlled and there is no deterioration until the 1 year; For the optic nerve, the injury of morphology is consistent with the function. Key words: Acute primary angle-closure glaucoma; Retinal nerve fiber layer; Mean defect; Pattern standard deviation

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急性原发性闭角型青光眼视神经损伤的评价

目的探讨急性原发性闭角型青光眼(APACG)急性发作后1年内视网膜神经纤维层(RNFL)厚度及视野的变化。方法前瞻性队列研究。连续招募30例APACG患者进行观察(发病眼为观察眼，同侧眼为对照)。在眼压控制24小时、1周、1个月、3个月、6个月、12个月后的6个时间点，分析眼压(IOP)、RNFL厚度和Humphrey周长。结果观察组术后24 h、1周RNFL平均厚度较对照组增厚(P < 0.05)。RNFL平均厚度与MD呈正相关(P <0.05)。结论APACG患者首次急性发作后RNFL厚度呈弥漫性增加，随时间延长逐渐变薄。IOP控制6个月后稳定;眼周损伤在IOP控制后1个月是可逆的，直到1年才出现恶化;视神经形态学损伤与功能损伤一致。关键词:急性原发性闭角型青光眼;视网膜神经纤维层;意味着缺陷;模式标准差

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中国实用眼科杂志

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9101

期刊介绍： China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association. China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.