Iron-laden blasts in refractory acute myeloid leukemia.

IF 0.6 4区医学 Q4 HEMATOLOGY

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-07-29 DOI:10.1007/s12308-023-00555-6

Christopher Vossen, Roeun Im, Pedro Horna

引用次数: 0

Abstract

We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls' Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.

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难治性急性髓性白血病中的含铁囊泡

我们报告了一例患有 DEK-NUP214 重排的难治性急性髓性白血病病例，该病例在 Wright-Giemsa 染色中显示循环中的单核细胞疱疹有大量绿色胞质颗粒。这些颗粒对 Perls 普鲁士蓝呈强阳性，与血色素沉积一致。这一以前未报道过的发现表明，白血病血块具有噬血体活性，很可能与单核细胞分化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hematopathology HEMATOLOGYPATHOLOGY-PATHOLOGY

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Journal of Hematopathology aims at providing pathologists with a special interest in hematopathology with all the information needed to perform modern pathology in evaluating lymphoid tissues and bone marrow. To this end the journal publishes reviews, editorials, comments, original papers, guidelines and protocols, papers on ancillary techniques, and occasional case reports in the fields of the pathology, molecular biology, and clinical features of diseases of the hematopoietic system. The journal is the unique reference point for all pathologists with an interest in hematopathology. Molecular biologists involved in the expanding field of molecular diagnostics and research on lymphomas and leukemia benefit from the journal, too. Furthermore, the journal is of major interest for hematologists dealing with patients suffering from lymphomas, leukemias, and other diseases. The journal is unique in its true international character. Especially in the field of hematopathology it is clear that there are huge geographical variations in incidence of diseases. This is not only locally relevant, but due to globalization, relevant for all those involved in the management of patients.