A case of esophageal squamous cell carcinoma accompanied by pancreatic and bile duct metastases: Successful treatment starts with an accurate diagnosis.

Regulatory Peptides Pub Date : 2023-10-01 Epub Date: 2022-09-03 DOI:10.4103/jcrt.jcrt_1891_21

Yuki Ito, Yoshihiro Ikura, Hiroaki Sawai, Tatsuya Osuga

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Abstract

Abstract: Pancreatic and bile duct metastases from esophageal cancer are extremely rare. We report a case of advanced esophageal cancer successfully treated with chemotherapy, selected on the basis of an accurate pathologic diagnosis. A 69-year-old man with chronic renal dysfunction presented with persistent abdominal pain and anorexia. Upper gastrointestinal endoscopy revealed an irregular-shaped tumor in the lower esophagus. Computed tomography and ultrasonography revealed swollen para-aortic lymph nodes, a pancreatic mass, and distal bile duct stenosis. Histopathological examination showed that all of the lesions were squamous cell carcinoma with unique immunohistochemical characteristics of p40+ and cytokeratin 7+. The final diagnosis was esophageal squamous cell carcinoma accompanied by lymph node, pancreas, and bile duct metastases. Taking his renal dysfunction into consideration, modified FOLFOX was administered as the first-line chemotherapy. The patient survived for 15 months since his first presentation. The favorable outcome was attributed to the accurate diagnosis based on comprehensive tissue sampling.

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一例伴有胰腺和胆管转移的食管鳞状细胞癌：成功的治疗始于准确的诊断。

摘要：食管癌的胰腺和胆管转移极为罕见。我们报告了一例在准确病理诊断基础上选择化疗并成功治疗的晚期食管癌病例。一名患有慢性肾功能不全的 69 岁男子出现持续性腹痛和厌食。上消化道内镜检查发现食管下段有一个形状不规则的肿瘤。计算机断层扫描和超声波检查发现主动脉旁淋巴结肿大、胰腺肿块和远端胆管狭窄。组织病理学检查显示，所有病变均为鳞状细胞癌，具有 p40+ 和细胞角蛋白 7+ 的独特免疫组化特征。最终诊断为食管鳞状细胞癌，并伴有淋巴结、胰腺和胆管转移。考虑到他的肾功能不全，改良 FOLFOX 被作为一线化疗方案。患者自首次就诊以来存活了 15 个月。良好的结果归功于基于全面组织取样的准确诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Peptides 医学-内分泌学与代谢

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.