Characterization and in vitro Evolution of Antibacterial Efficacy of Novel Hesperidin Microemulsion

Abstract

Natural products used in the traditional systems of medicine exhibit a various and promising resource in human health. However, these products are often characterized for their chemical composition as well as mechanisms of action. Considering the bacterial infections play an important role in human diseases, it is necessary to develop new antibacterial herbal products. The aim of this study was to isolation and structural identification of hesperidin from Citrus sinensis L. and to formulate hesperidin loaded to water-in-oil (w/o) microemulsion as an inovative formulation for bactericidal treatment. This present study indicates that hesperidin microemulsion has antibacterial activity against various types of bacteria according to MIC method. All strains were showed logaritmic reduction. These findings indicated that the microemulsion as a drug carrier, especially hesperidin formulation, may be used as an effective antibacterial therapy.