The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder.

Oğuzhan Kılınçel, Ş. Kılınçel, Cem Gündüz, Ş. Cangür, C. Akkaya
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引用次数: 2

Abstract

OBJECTIVE In this study, we aimed to investigate the effect of the clozapine on the course of the rapid cycling Bipolar Affective Disorder. METHOD The study group was formed with the patients aged between 18 and 65 years of age, who met the criteria for the diagnosis of Bipolar Affective Disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th Edition, with rapid cycling characteristics. Variables like the number of mania and depressive episodes, the days spent in mania and in depression and the number of hospitalization and attempted suicide, in the year before starting clozapine were determined and compared with the annual data after starting the clozapine. RESULTS Eleven female and two male patients who met the inclusion criteria were included in this study. The group`s average daily use of clozapine was 180 mg (25-600 mg). There was a statistically significant difference in the number of days spent in the depression, the days spent in the mania, the number of depressive episodes and manic episodes, the number of hospitalizations and the suicide attempts after the clozapine use. CONCLUSION In this study, it was determined that clozapine was effective as a mood stabilizer in Bipolar Affective Disorder treatment. The results show that clozapine reduces the episode frequency and the duration in rapid cycling Bipolar Affective Disorder which does not respond to all conventional treatments, including lithium, valproic acid, carbamazepine and antipsychotic drugs.
氯氮平作为情绪调节剂在快速循环双相情感障碍治疗中的作用。
目的探讨氯氮平对快速循环型双相情感障碍病程的影响。方法选取年龄在18 ~ 65岁,符合《精神障碍诊断与统计手册》第4版双相情感障碍诊断标准,且具有快速循环特征的患者为研究对象。确定开始使用氯氮平前一年躁狂和抑郁发作次数、躁狂和抑郁天数、住院和企图自杀次数等变量,并将其与开始使用氯氮平后的年度数据进行比较。结果符合纳入标准的患者包括女性6例和男性2例。该组平均每日氯氮平使用量为180毫克(25-600毫克)。在抑郁的天数,躁狂的天数,抑郁发作和躁狂发作的次数,住院次数和使用氯氮平后的自杀企图方面有统计学上的显著差异。结论本研究确定氯氮平作为情绪稳定剂治疗双相情感障碍是有效的。结果表明氯氮平可减少快速循环双相情感障碍的发作频率和持续时间,而所有常规治疗方法,包括锂离子、丙戊酸、卡马西平和抗精神病药物均无反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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